Reactome | Leprince, D

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created	[InstanceEdit:4090291] May, B, 2013-08-13
dbId	4090360
displayName	Leprince, D
firstname	Dominique
initial	D
publications	[LiteratureReference:5084111] Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes [LiteratureReference:8953844] DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair [LiteratureReference:8955677] Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells [LiteratureReference:5084074] Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins [LiteratureReference:4090292] An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity [LiteratureReference:8955676] HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs)
schemaClass	Person
surname	Leprince

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