CRMPs are a small family of plexinA-interacting cytosolic ph...

created [InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
dbId 399741
displayName CRMPs are a small family of plexinA-interacting cytosolic ph...
literatureReference
modified [InstanceEdit:421778] D'Eustachio, P, 2009-05-20 18:44:38
schemaClass Summation
text CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse.
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