Reactome | The effective activation of the EPH kinase domain requires o...

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created	[InstanceEdit:3928288] Garapati, P V, 2013-07-22
dbId	3928275
displayName	The effective activation of the EPH kinase domain requires o...
literatureReference	[LiteratureReference:3928081] Kinetic analysis of the binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay [LiteratureReference:3928014] Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses [LiteratureReference:3928159] Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
modified	[InstanceEdit:4655451] Garapati, P V, 2013-10-03
schemaClass	Summation
text	The effective activation of the EPH kinase domain requires oligomerisation of EPH receptors and ephrins (EFNs) (Davis et al. 1994). Tetrameric EPH:EFN complexes aggregate into higher-ordered EPH:EFN clusters through several low-affinity EPH:EPH and EFN:EFN interactions, which may be responsible for EPH:EFN signaling (Stein et al. 1998, Pabbisetty et al. 2007).

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