GADS (Grb2-related adaptor protein 2) plays a crucial role ...

created [InstanceEdit:389386] Garapati, P V, 2009-01-07 10:50:48
dbId 389390
displayName GADS (Grb2-related adaptor protein 2) plays a crucial role ...
literatureReference
modified [InstanceEdit:9927269] Tiwari, Krishna, 2024-11-05
schemaClass Summation
text GADS (Grb2-related adaptor protein 2) plays a crucial role in CD28-mediated NF-kB activation, which is vital for effective T cell activation and immune responses. This signal is mediated by the direct binding of GADS to the YMNM motif in the cytoplasmic tail of CD28. Additionally, the proline-rich PxxP motif in CD28 is also required for the optimal association of Gads with the CD28 signaling complex. These interactions help bridge CD28 with other intracellular signaling pathways, ensuring robust NF-kB activation and subsequent T cell proliferation and cytokine production (Watanabe et al. 2006).
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