Reactome | NuMA can interact with microtubules by direct binding to tub...

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created	[InstanceEdit:380489] Matthews, L, 2008-11-13 13:01:11
dbId	380479
displayName	NuMA can interact with microtubules by direct binding to tub...
literatureReference	[LiteratureReference:380471] Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules [LiteratureReference:380494] NuMA assembles into an extensive filamentous structure when expressed in the cell cytoplasm [LiteratureReference:380480] Induction of a regular nuclear lattice by overexpression of NuMA [LiteratureReference:380472] Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice
modified	[InstanceEdit:8983764] Orlic-Milacic, Marija, 2017-03-27
schemaClass	Summation
text	NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al. 1996, Gueth-Hallonet et al.1998, Harborth et al.1999) apparently as a result of dimerization of the NuMA rod domains followed by association of multiple NuMA dimers through their tail domains.

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