Reactome | Plk1 is associated with the centrosomes early in mitosis (Go...

Schema > Summation > Entries

Plk1 is associated with the centrosomes early in mitosis (Go... Show undefined attributes

created	[InstanceEdit:380314] Matthews, L, 2008-11-11 14:52:38
dbId	380299
displayName	Plk1 is associated with the centrosomes early in mitosis (Go...
literatureReference	[LiteratureReference:380306] Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function [LiteratureReference:383235] Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes [LiteratureReference:383211] The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1 [LiteratureReference:383224] Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance [LiteratureReference:383259] Probing cell-division phenotype space and Polo-like kinase function using small molecules [LiteratureReference:383251] Roles of polo-like kinase 1 in the assembly of functional mitotic spindles [LiteratureReference:383230] Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis
modified	[InstanceEdit:383220] Matthews, L, 2008-11-24 15:16:28
schemaClass	Summation
text	Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, L�n�rt et al, 2007).

Referrals

(summation)

[Reaction:R-HSA-380311] Recruitment of Plk1 to centrosomes

© 2026 Reactome

Cite Us!