Reactome | Nidogen-1 (entactin) is a member of the nidogen family of ba...

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created	[InstanceEdit:3791337] Jupe, S, 2013-07-05
dbId	3791305
displayName	Nidogen-1 (entactin) is a member of the nidogen family of ba...
literatureReference	[LiteratureReference:1592404] Developmental and pathogenic mechanisms of basement membrane assembly [LiteratureReference:1592301] Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling [LiteratureReference:1564108] Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites [LiteratureReference:1566947] Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase [LiteratureReference:1592280] Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases [LiteratureReference:2537521] Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme
schemaClass	Summation
text	Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). MMPs 3, 7 (Mayer et al. 1993), 1, 9, (Sires et al. 1993), 12 (Gronski et al. 1997), 14, 15 (d'Ortho et al. 1997), 19 (Stracke et al. 2000) and leukocyte elastase (Mayer et al. 1993) can all degrade Nidogen-1.

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