Carbohydrate sulfotransferase 3 (CHST3) transfers sulfate (S...

created [InstanceEdit:3636794] Jassal, B, 2013-05-29
dbId 3636784
displayName Carbohydrate sulfotransferase 3 (CHST3) transfers sulfate (S...
modified [InstanceEdit:5607512] Jassal, Bijay, 2014-07-11
schemaClass Summation
text Carbohydrate sulfotransferase 3 (CHST3) transfers sulfate (SO4(2-)) to position 6 of N-acetylgalactosamine (GalNAc) residues of chondroitin-containg proteins resulting in chondroitin sulfate (CS), the predominant glycosaminoglycan present in cartilage. Defects in CHST3 result in spondyloepiphyseal dysplasia with congenital joint dislocations (SEDCJD; MIM:143095), a bone dysplasia clinically characterized by severe progressive kyphoscoliosis (abnormal curvature of the spine), arthritic changes with joint dislocations and short stature in adulthood (Unger et al. 2010).
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