ATF2 (activating transcription factor 2) is a basic leucine ...
| created | [InstanceEdit:3318432] Jupe, S, 2013-04-26 |
| dbId | 3318391 |
| displayName | ATF2 (activating transcription factor 2) is a basic leucine ... |
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| modified | [InstanceEdit:4657005] Jupe, S, 2013-10-04 |
| schemaClass | Summation |
| text | ATF2 (activating transcription factor 2) is a basic leucine zipper (bZIP) protein and member of the activator protein-1 (AP-1) family (Wagner et al. 2001). The basic region of ATF2 binds DNA while the leucine zipper region allows dimerization with partners. ATF2 is a histone acetyltransferase (HAT), which specifically acetylates histones H2B and H4 in vitro. ATF2 is sequentially phosphorylated on threonine residues T69 and T71 by protein kinases ERK1/2 and p38 (van Dam et al. 1995, Livingstone et al. 1995, Ouwens et al. 2002, Baan et al. 2009). This phosphorylated form has increased HAT activity (Kawasaki et al. 2000). |
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