Reactome | Tripartite motif (TRIM) family member TRIM56 was shown to in...

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created	[InstanceEdit:3249349] Shamovsky, V, 2013-04-08
dbId	3249347
displayName	Tripartite motif (TRIM) family member TRIM56 was shown to in...
literatureReference	[LiteratureReference:3244658] TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination [LiteratureReference:1964498] The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
modified	[InstanceEdit:3558425] Shamovsky, V, 2013-05-20
schemaClass	Summation
text	Tripartite motif (TRIM) family member TRIM56 was shown to interact with STING upon DNA stimulation promoting lysine 63-linked ubiquitination of STING and type I IFN induction (Tsuchida T et al. 2010). Another member of the family TRIM32 has also been implicated in K63-linked ubiquitination of STING (Zhang J et al. 2012).

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