Reactome | Harvey, S

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created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
dbId	3244627
displayName	Harvey, S
firstname	Scott
initial	S
publications	[LiteratureReference:3247963] The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis [LiteratureReference:3247970] The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease [LiteratureReference:3247960] Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease [LiteratureReference:3244662] The TREX1 exonuclease R114H mutation in Aicardi-Gouti�res syndrome and lupus reveals dimeric structure requirements for DNA degradation activity [LiteratureReference:3247886] The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering [LiteratureReference:3248000] Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome [LiteratureReference:3247939] Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus
schemaClass	Person
surname	Harvey

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