Reactome | ETS1 and ETS2, activated by RAS/RAF/MAP kinase cascade, bind...

Schema > Summation > Entries

created	[InstanceEdit:3209104] Orlic-Milacic, M, 2013-03-01
dbId	3209103
displayName	ETS1 and ETS2, activated by RAS/RAF/MAP kinase cascade, bind...
literatureReference	[LiteratureReference:3200021] Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence [LiteratureReference:8862796] Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
modified	[InstanceEdit:9645179] Orlic-Milacic, Marija, 2019-05-06
schemaClass	Summation
text	ETS1 and ETS2, activated by RAS/RAF/MAP kinase cascade, bind the promoter of p16INK4A in the CDKN2A locus (Ohtani et al. 2001). CDKN2A locus also encodes p14ARF (p19ARF in mouse), but from a different promoter and in a different reading frame. While p16INK4A and p14ARF use different exon 1, (exon 1-alpha and exon 1-beta, respectively), they share exons 2 and 3. However, because the reading frames are different, there is no amino acid sequence similarity between the two proteins (Quelle et al. 1995).

(summation)

Cite Us!