The cytosolic protein beta-catenin is known as a transcripti...

created [InstanceEdit:3134899] Shamovsky, V, 2013-02-13
dbId 3134889
displayName The cytosolic protein beta-catenin is known as a transcripti...
modified [InstanceEdit:3301374] Shamovsky, V, 2013-04-22
schemaClass Summation
text The cytosolic protein beta-catenin is known as a transcriptional cofactor in Wnt signaling pathway. Beta-catenin has been also implicated in LRRFIP1-mediated induction of type I IFN. Beta-catenin was shown to bind Lrrfip1 in L. monocytogenes-infected mouse macrophages but not in resting macrophages (Yang P et al 2010). The interaction of beta-catenin and LRRFIP1 was also reported for human proteins when they were co-expressed in human embryonic kidney 293T (HEK293T) cells followed by co-immunoprecipitation assay. The co-immunoprecipitation results were consistent with the GST-pulldown data (Lee YH and Stallcup MR 2006).
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