NOTCH1 HD domain mutants are cleaved at S2 and S3 sites to p...

created [InstanceEdit:2902225] Orlic-Milacic, M, 2013-01-03
dbId 2902226
displayName NOTCH1 HD domain mutants are cleaved at S2 and S3 sites to p...
modified [InstanceEdit:2981031] Orlic-Milacic, M, 2013-01-14
schemaClass Summation
text NOTCH1 HD domain mutants are cleaved at S2 and S3 sites to produce NEXT1 and NICD1 fragments, respectively, in the absence of DLL/JAG ligand binding, although they are responsive to DLL/JAG ligands. NOTCH1 mutants containing in cis mutations in the HD and PEST domains are expected to be constitutively cleaved at the S2 site by ADAM10/17, like NOTCH1 HD domain mutants (Malecki et al. 2006), resulting in release of NEXT1 PEST domain mutant fragments.
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