Reactome | gain_of_function via gene

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gain_of_function via gene_fusion Show undefined attributes

created	[InstanceEdit:2666276] Orlic-Milacic, M, 2012-11-23
dbId	2666275
displayName	gain_of_function via gene_fusion
functionalStatusType	[FunctionalStatusType:2426108] gain_of_function
schemaClass	FunctionalStatus
structuralVariant	[SequenceOntology:2318478] gene_fusion

Referrals

(functionalStatus)

[EntityFunctionalStatus:2666274] gain_of_function of NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane]
[EntityFunctionalStatus:9673675] gain_of_function of membrane-tethered PDGFR fusions [plasma membrane]
[EntityFunctionalStatus:9673666] gain_of_function of membrane-tethered PDGFR fusion dimers [plasma membrane]
[EntityFunctionalStatus:9673676] gain_of_function of cytosolic PDGFR fusion dimers [cytosol]
[EntityFunctionalStatus:9673668] gain_of_function of cytosolic PDGFR fusions [cytosol]
[EntityFunctionalStatus:9672146] gain_of_function of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]
[EntityFunctionalStatus:9672149] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672151] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672155] gain_of_function of PDGFR mutant receptors [plasma membrane]
[EntityFunctionalStatus:9672147] gain_of_function of PDGFR mutant dimers [plasma membrane]
[EntityFunctionalStatus:9672150] gain_of_function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
[EntityFunctionalStatus:9672144] gain_of_function of p-11Y PDGFR mutant dimers:PI3K [plasma membrane]
[EntityFunctionalStatus:8853297] gain_of_function of FGFR2 fusion dimers [plasma membrane]
[EntityFunctionalStatus:8853294] gain_of_function of FGFR2 fusions [plasma membrane]
[EntityFunctionalStatus:8853287] gain_of_function of FGFR3 fusion dimers [plasma membrane]
[EntityFunctionalStatus:8853291] gain_of_function of FGFR3 fusions [plasma membrane]
[EntityFunctionalStatus:9632021] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:8853292] gain_of_function of plasma membrane FGFR1 fusions [plasma membrane]
[EntityFunctionalStatus:8853288] gain_of_function of Plasma membrane FGFR1 fusion dimers [plasma membrane]
[EntityFunctionalStatus:5654474] gain_of_function of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol]
[EntityFunctionalStatus:5654512] gain_of_function of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
[EntityFunctionalStatus:9630091] gain_of_function of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
[EntityFunctionalStatus:5654506] gain_of_function of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
[EntityFunctionalStatus:5654441] gain_of_function of p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol]
[EntityFunctionalStatus:5654504] gain_of_function of p-FGFR1 mutant fusions:PI3K [cytosol]
[EntityFunctionalStatus:5654534] gain_of_function of BCR-p-FGFR1 fusion mutant dimer [cytosol]
[EntityFunctionalStatus:5654559] gain_of_function of pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
[EntityFunctionalStatus:5654556] gain_of_function of pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
[EntityFunctionalStatus:5654476] gain_of_function of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol]
[EntityFunctionalStatus:5654473] gain_of_function of p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1 [cytosol]
[EntityFunctionalStatus:5655333] gain_of_function of Activated FGFR1 mutants:FRS2 [plasma membrane]
[EntityFunctionalStatus:5655256] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[EntityFunctionalStatus:5654483] gain_of_function of cytosolic FGFR1 fusion mutants [cytosol]
[EntityFunctionalStatus:5654536] gain_of_function of cytosolic FGFR1 fusion mutant dimers [cytosol]
[EntityFunctionalStatus:5654508] gain_of_function of Activated FGFR1 mutants and fusions [plasma membrane]
[EntityFunctionalStatus:5654444] gain_of_function of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]
[EntityFunctionalStatus:5654440] gain_of_function of Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol]
[EntityFunctionalStatus:6802904] gain_of_function of p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol]
[EntityFunctionalStatus:6802860] gain_of_function of BRAF/RAF fusion dimers [cytosol]
[EntityFunctionalStatus:6802898] gain_of_function of p-BRAF/RAF fusion dimers [cytosol]
[EntityFunctionalStatus:6802900] gain_of_function of p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol]
[EntityFunctionalStatus:6802902] gain_of_function of p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol]

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