NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from...

created [InstanceEdit:2660827] Orlic-Milacic, M, 2012-11-23
dbId 2660817
displayName NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from...
modified [InstanceEdit:2981031] Orlic-Milacic, M, 2013-01-14
schemaClass Summation
text NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from fusion of NOTCH1 intron 24 with the promoter of T-cell receptor TCRB, lacks extracellular EGF repeats involved in ligand binding and is not able to bind to DLL4 (Ellisen et al. 1991).
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