Reactome | Kaufman, RJ

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Kaufman, RJ Show undefined attributes

created	[InstanceEdit:264390] May, B, 2008-03-30 13:53:45
dbId	264383
displayName	Kaufman, RJ
initial	RJ
modified	[InstanceEdit:264407] May, B, 2008-03-30 14:05:39
publications	[LiteratureReference:381139] The mammalian unfolded protein response [LiteratureReference:380997] The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes [LiteratureReference:381049] Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum [LiteratureReference:535482] A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells [LiteratureReference:535551] The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain [LiteratureReference:535483] The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response [LiteratureReference:381152] Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response [LiteratureReference:535557] Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds [LiteratureReference:535571] The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
schemaClass	Person
surname	Kaufman

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