Reactome | ESPL1 (separin i.e. separase) cleaves RAD21 (SCC1) subunit o...

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created	[InstanceEdit:2500295] Orlic-Milacic, M, 2012-10-02
dbId	2500294
displayName	ESPL1 (separin i.e. separase) cleaves RAD21 (SCC1) subunit o...
literatureReference	[LiteratureReference:163039] Cohesin cleavage by separase required for anaphase and cytokinesis in human cells [LiteratureReference:163990] Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 [LiteratureReference:2545212] HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
modified	[InstanceEdit:2550408] Orlic-Milacic, M, 2012-11-01
schemaClass	Summation
text	ESPL1 (separin i.e. separase) cleaves RAD21 (SCC1) subunit of centromeric cohesin at two sites that conform to the consensus separase recognition site E-X-X-R: after arginine residue R172 and after arginine residue R450 (Hauf et al. 2001). Phosphorylation of RAD21 at the serine residue S454 by PLK1 in prometaphase facilitates ESPL1-mediated cleavage of RAD21 at the C-terminal cleavage site R450 (Hauf et al. 2005). The N-terminal and C-terminal RAD21 cleavage fragments remain bound to the rest of the cohesin complex (Deardorff et al. 2012). It is not clear whether RAD21 middle fragment also continues to be associated with cohesin.

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