Reactome | Netrins are a family of extracellular proteins that include ...

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created	[InstanceEdit:2447197] Jupe, S, 2012-08-13
dbId	2447203
displayName	Netrins are a family of extracellular proteins that include ...
literatureReference	[LiteratureReference:2396418] Binding of netrin-4 to laminin short arms regulates basement membrane assembly [LiteratureReference:2426461] Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells
modified	[InstanceEdit:3597687] Jupe, S, 2013-05-22
schemaClass	Summation
text	Netrins are a family of extracellular proteins that include axonal guidance factors. Their N-terminal domains are homologous to the LN domains of laminins. Netrin-4 (but not other forms) can bind laminin gamma-1 and gamma-3 short arms in basement membrane, suggesting a role in regulating basement membrane formation (Schneiders et al. 2007). Netrin-4 has been found associated in a functional complex with laminin gamma-1 chain and integrin alpha6beta1, suggesting a role in regulation of neurogenesis in the olfactory system (Staquicini et al. 2009).

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