Reactome | Three tyrosine residues at positions 771, 783 and 1254 in PL...

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created	[InstanceEdit:2424330] Garapati, P V, 2012-07-23
dbId	2424406
displayName	Three tyrosine residues at positions 771, 783 and 1254 in PL...
literatureReference	[LiteratureReference:2424332] PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254 [LiteratureReference:2028806] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk [LiteratureReference:2424320] Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling
modified	[InstanceEdit:2426436] Garapati, P V, 2012-08-02
schemaClass	Summation
text	Three tyrosine residues at positions 771, 783 and 1254 in PLCgamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for PLC-gamma1 activation. In myeloid cells phosphorylation of the tyrosine residues of PLC-gamma1 is mediated by SYK and BTK kinases (Ormsby et al. 2010, Kim et al. 1994, Law et al. 1996, Watanabe et al. 2001).

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