Reactome | The arginine residue at position 38 of PIK3CA (R38) is locat...

Schema > Summation > Entries

created	[InstanceEdit:2399573] Orlic-Milacic, M, 2012-07-11
dbId	2399570
displayName	The arginine residue at position 38 of PIK3CA (R38) is locat...
literatureReference	[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
schemaClass	Summation
text	The arginine residue at position 38 of PIK3CA (R38) is located at a contact site between the ABD and kinase domains of PIK3CA. Substitution of this arginine residue with histidine in PIK3CA R38H mutant is likely to disrupt the interaction between the ABD domain and the kinase domain, causing a confomrational change of the kinase domain that leads to increased enzymatic activity (Huang et al. 2007). PIK3CA R38H mutant shows reduced PIK3R1 binding and modestly increased catalytic activity (measured indirectly, via AKT1 phosphorylation) under serum starved conditions (Zhao et al. 2005).

(summation)

Cite Us!