Reactome | PIP3 generated by PI3K recruits AKT (also known as protein k...

Schema > Summation > Entries

created	[InstanceEdit:2326767] Orlic-Milacic, M, 2012-06-18
dbId	2326765
displayName	PIP3 generated by PI3K recruits AKT (also known as protein k...
literatureReference	[LiteratureReference:199317] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B [LiteratureReference:870254] The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation [LiteratureReference:870256] The role of Akt3 in Platelet Activation
schemaClass	Summation
text	PIP3 generated by PI3K recruits AKT (also known as protein kinase B) to the membrane, through its PH (pleckstrin-homology) domains. The binding of PIP3 to the PH domain of AKT is the rate-limiting step in AKT activation (Scheid et al. 2002). In mammals there are three AKT isoforms (AKT1-3) encoded by three separate genes. The three isoforms share a high degree of amino acid identity and have indistinguishable substrate specificity in vitro. However, isoform-preferred substrates in vivo cannot be ruled out. The relative expression of the three isoforms differs in different mammalian tissues: AKT1 is the predominant isoform in the majority of tissues, AKT2 is the predominant isoform in insulin-responsive tissues, and AKT3 is the predominant isoform in brain and testes. All 3 isoforms are expressed in human and mouse platelets (Yin et al. 2008; O'Brien et al. 2008). Note: all data in the pathway refer to AKT1, which is the most studied.

(summation)

Cite Us!