Reactome | Collagen VII forms anchoring fibrils, composed of antiparall...

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created	[InstanceEdit:2213196] Jupe, S, 2012-04-30
dbId	2213206
displayName	Collagen VII forms anchoring fibrils, composed of antiparall...
literatureReference	[LiteratureReference:2213197] Can type VII collagen injections cure dystrophic epidermolysis bullosa? [LiteratureReference:2210345] Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen [LiteratureReference:2172444] Collagens
schemaClass	Summation
text	Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptides are then removed by bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Gordon & Hahn 2010).

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