Reactome | TGF-beta (TGFB1) stimulates formation of a complex of SP1 tr...

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created	[InstanceEdit:2187306] Orlic-Milacic, M, 2012-04-09
dbId	2187308
displayName	TGF-beta (TGFB1) stimulates formation of a complex of SP1 tr...
literatureReference	[LiteratureReference:1181277] Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
modified	[InstanceEdit:2197823] Orlic-Milacic, M, 2012-04-16
schemaClass	Summation
text	TGF-beta (TGFB1) stimulates formation of a complex of SP1 transcription factor and SMAD2/3:SMAD4 heterotrimer. SMAD2 and SMAD4 bind to SP1 directly, through their C- and N-terminus, respectively (Feng et al. 2000).

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