Reactome | SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano e...

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created	[InstanceEdit:2186766] Orlic-Milacic, M, 2012-04-05
dbId	2186764
displayName	SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano e...
literatureReference	[LiteratureReference:2186730] Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation [LiteratureReference:2186729] Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling [LiteratureReference:2186628] TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
modified	[InstanceEdit:2197823] Orlic-Milacic, M, 2012-04-16
schemaClass	Summation
text	SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano et al. 2007) or SMURF2 (Bonni et al. 2001) are degraded in a proteasome dependent way, enabling transcription of SMAD2/3:SMAD4 target genes.

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