Reactome | c-Abl is a ubiquitously-expressed non-receptor tyrosine kina...

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created	[InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09
dbId	216932
displayName	c-Abl is a ubiquitously-expressed non-receptor tyrosine kina...
literatureReference	[LiteratureReference:216999] Arg encodes a widely expressed 145 kDa protein-tyrosine kinase [LiteratureReference:217096] Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation [LiteratureReference:217104] The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases [LiteratureReference:216973] Regulation of Rad51 function by c-Abl in response to DNA damage [LiteratureReference:217133] Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
modified	[InstanceEdit:391641] Saxena, A, 2009-02-23 15:55:32
schemaClass	Summation
text	c-Abl is a ubiquitously-expressed non-receptor tyrosine kinase, which is activated in an ATM-dependent manner upon DNA damage. c-Abl plays a role in growth arrest and apoptosis as well as in DNA repair; the latter mediated by c-Abl phosphorylating Tyr46 on Rad51 (This residue corresponds to tyrosine 54 of human Rad51). Arg (Abl related gene) is another member of the Ableson cytoplasmic tyrosine kinase family. Its known functions are redundant with c-Abl.

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