Reactome | SMAD7 binds to phosphorylated TGFBR1 (TGF-beta receptor I), ...

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created	[InstanceEdit:2169034] Orlic-Milacic, M, 2012-03-27
dbId	2169033
displayName	SMAD7 binds to phosphorylated TGFBR1 (TGF-beta receptor I), ...
literatureReference	[LiteratureReference:178228] Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation [LiteratureReference:178173] Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation [LiteratureReference:2176422] NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
modified	[InstanceEdit:2197821] Orlic-Milacic, M, 2012-04-16
schemaClass	Summation
text	SMAD7 binds to phosphorylated TGFBR1 (TGF-beta receptor I), thereby recruiting SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) ubiquitin ligases to the activated TGF-beta receptor complex. This is based on experiments in which recombinant mouse Smad7 was used together with recombinant human ubiquitin ligases and TGF-beta receptors.

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