Reactome | Release of tyrosine-phosphorylated SHC from the insulin rece...

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created	[InstanceEdit:211573] Schmidt, EE, 2008-02-07 14:01:08
dbId	211572
displayName	Release of tyrosine-phosphorylated SHC from the insulin rece...
literatureReference	[LiteratureReference:8984404] Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner [LiteratureReference:8984407] Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
modified	[InstanceEdit:8984457] Duenas, Corina, 2017-04-06
schemaClass	Summation
text	Release of tyrosine-phosphorylated SHC from the insulin receptor triggers a cascade of signalling events via SOS, RAF and the MAP kinases (Sasaoka et al. 1996, Kleiman et al.2011). This is a black box event since this dissociation is inferred from other reaction which show association and dissociation for this protein under EGF stimulation (Kleiman et al. 2011).

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