Stromal fibroblasts secrete multiple matrix metalloproteinas...

created [InstanceEdit:211109] Garapati, P V, 2008-01-28 10:30:53
dbId 211111
displayName Stromal fibroblasts secrete multiple matrix metalloproteinas...
literatureReference
modified [InstanceEdit:211548] Garapati, P V, 2008-02-05 13:52:09
schemaClass Summation
text Stromal fibroblasts secrete multiple matrix metalloproteinases (MMP)1 that can promote tumor cell growth, survival, invasion, angiogenesis, and metastasis. Basigin on the surface of carcinoma cells, stimulates production of MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), and MMP-3 (stromelysin). Basigin has been shown to co-immunoprecipitate with caveolin-1. The second Ig domain of Basigin is required for this association, which leads to decreased Besigin self-association on the cell surface. Therefore, caveolin-1 is a negative regulator of CD147 self-association, and its MMP-inducing activity.
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