Although it has not been rigourously established, there is s...

created [InstanceEdit:2077541] Rothfels, K, 2012-01-27
dbId 2077542
displayName Although it has not been rigourously established, there is s...
modified [InstanceEdit:2085639] Rothfels, K, 2012-02-05
schemaClass Summation
text Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established.
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