The binding of CD4/CD8 to non-polymorphic regions of MHC bri...

created [InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId 202381
displayName The binding of CD4/CD8 to non-polymorphic regions of MHC bri...
literatureReference
modified [InstanceEdit:212486] Garapati, P V, 2008-02-12 11:49:39
schemaClass Summation
text The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members.
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