Reactome | L-selectin plays a major role in leukocyte traffic through l...

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created	[InstanceEdit:199493] de Bono, B, 2007-07-11 09:38:48
dbId	199498
displayName	L-selectin plays a major role in leukocyte traffic through l...
literatureReference	[LiteratureReference:199494] GlyCAM-1 supports leukocyte rolling in flow: evidence for a greater dynamic stability of L-selectin rolling of lymphocytes than of neutrophils [LiteratureReference:199499] Hematopoietic stem cell antigen CD34: role in adhesion or homing [LiteratureReference:199048] Expression of potential lymphocyte trafficking mediator molecules in the mammary gland
schemaClass	Summation
text	L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules. Both MAdCAM and GlyCAM-1 are major L-selectin ligands produced by these venules and mediate leukocyte rolling, particularly in lymphocytes. They are also expressed in mammary tissue and play an important role in the transfer of immune cells into milk secretions. The adhesive properties of CD34 and its potential role in homing lymphocytes to lymphoid tissues mimics the mechanims leukocytes adopt to travel to inflammatory sites.

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