Reactome | 4-methylcholesta-8(9),24-dien-3beta-ol, NADPH + H+, and O2 r...

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created	[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
dbId	194675
displayName	4-methylcholesta-8(9),24-dien-3beta-ol, NADPH + H+, and O2 r...
literatureReference	[LiteratureReference:194705] Stoichiometry of 4-methyl sterol oxidase of rat liver microsomes [LiteratureReference:194672] Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase.
schemaClass	Summation
text	4-methylcholesta-8(9),24-dien-3beta-ol, NADPH + H+, and O2 react to form 4-carboxycholesta-8(9),24-dien-3beta-ol, NADP+, and H2O. This reaction, in the endoplasmic reticulum, is catalyzed by SC4MOL (C-4 methylsterol oxidase). The human enzyme has been identified based on its sequence similarity to yeast methyl sterol oxidase (ERG25) and the ability of the cloned human gene to rescue ERG25-deficient yeast cells (Li and Kaplan 1996). The mechanism and stoichiometry of the reaction have been inferred from studies of partially purified rat enzyme (Gaylor et al. 1975; Fukushima et al. 1981).

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