Reactome | Synthesis of full length complementary viral RNA (cRNA) requ...

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created	[InstanceEdit:192697] Gillespie, ME, 2007-02-07 04:51:41
dbId	192843
displayName	Synthesis of full length complementary viral RNA (cRNA) requ...
literatureReference	[LiteratureReference:169007] Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoprotein [LiteratureReference:192910] Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer [LiteratureReference:192637] Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication
schemaClass	Summation
text	Synthesis of full length complementary viral RNA (cRNA) requires that vRNA transcription initiates without the help of a host cell methyl RNA cap as a primer (Crow, 2004; Vreede, 2004; Deng, 2006), and that it proceeds to the 5' end of the vRNA template without stuttering on the sub-terminal poly-U sequence. Free viral NP protein appears to play a central role in enabling both of these features of cRNA synthesis, although the molecular details of its role remain unclear (Shapiro, 1988; Medcalf, 1999; Mullin, 2004).

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