Reactome | SKP2 is degraded by the anaphase promoting complex/Cyclosome...

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created	[InstanceEdit:188186] Matthews, L, 2006-10-02 06:21:46
dbId	188188
displayName	SKP2 is degraded by the anaphase promoting complex/Cyclosome...
literatureReference	[LiteratureReference:187848] Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase [LiteratureReference:187864] Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
modified	[InstanceEdit:9687090] Orlic-Milacic, Marija, 2020-05-06
schemaClass	Summation
text	SKP2 is degraded by the anaphase promoting complex/Cyclosome and its activator FZR1 (Cdh1) [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination SKP2 and, thus, plays a critical role in controlling the M/G1 transition (mitotic exit). APC/C:Cdh1-mediated degradation of SKP2 depends on RB1, as RB1 recruits SKP2 to the APC/C:Cdh1 complex, by simultaneously interacting with SKP2 and FZR1. RB1 does not undergo APC/C:Cdh1-mediated ubiquitination (Binne et al. 2007).

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