Reactome | NEXT4 fragment of NOTCH4 is further cleaved at the S3 site b...

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created	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId	178973
displayName	NEXT4 fragment of NOTCH4 is further cleaved at the S3 site b...
literatureReference	[LiteratureReference:9604291] Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function [LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
modified	[InstanceEdit:9605034] Orlic-Milacic, Marija, 2018-04-06
schemaClass	Summation
text	NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004).

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