Mitochondrial ECHS1 (enoyl-CoA hydratase) hexamer catalyzes ...

created [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId 178949
displayName Mitochondrial ECHS1 (enoyl-CoA hydratase) hexamer catalyzes ...
modified [InstanceEdit:9672919] D'Eustachio, Peter, 2020-01-03
schemaClass Summation
text Mitochondrial ECHS1 (enoyl-CoA hydratase) hexamer catalyzes the reversible addition of water to MACR-CoA (methacrylyl-CoA) to form bHIB-CoA (beta-hydroxybutyryl-CoA). Partially purified ECHS1 catalyzes this reaction with moderate efficiency in vitro, and patients deficient in the enzyme accumulate and excrete MACR-CoA (Yamada et al. 2015).
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