Reactome | A major known function of the 9-1-1 complex is to recruit Ch...

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created	[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
dbId	176243
displayName	A major known function of the 9-1-1 complex is to recruit Ch...
literatureReference	[LiteratureReference:176251] Evidence that DNA damage detection machinery participates in DNA repair [LiteratureReference:176268] Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin [LiteratureReference:176142] The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1 [LiteratureReference:176155] The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair [LiteratureReference:176299] Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe
schemaClass	Summation
text	A major known function of the 9-1-1 complex is to recruit Chk1 to stalled replication forks for activation by ATR. However, the presence of the 9-1-1 complex also alters the ability of Rad17 to become phoshorylated, perhaps suggesting that 9-1-1 may also serve to recruit a subset of ATR substrates. The 9-1-1 complex has also been found to interact with base excision repair factors human DNA polymerase beta, flap endonuclease FEN1, and the S. pombe MutY homolog (SpMYH), indicating that 9-1-1 also plays a direct role in DNA repair.

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