Reactome | The viral RNP complex is exported from the nucleus via the h...

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created	[InstanceEdit:168988] D'Eustachio, P, 2005-11-22 21:19:36
dbId	169021
displayName	The viral RNP complex is exported from the nucleus via the h...
literatureReference	[LiteratureReference:192782] Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes [LiteratureReference:195636] Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import [LiteratureReference:195624] The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins
modified	[InstanceEdit:195637] Gillespie, ME, 2007-04-09 18:37:11
schemaClass	Summation
text	The viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 to form an export complex. Rather, an additional viral protein, nuclear export protein (NEP/NS2), acts as an adaptor, binding the viral matrix M1 protein and CRM1, thus linking the viral RNP with CRM1 (Martin, 1991; O'Neill, 1998; Neumann, 2000; Akarsu, 2003). The CRM1/exportin-1 complex recruits additional host cell proteins, and traverses the nuclear pore into the cytosol.

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