Reactome | Gay, NJ

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Gay, NJ Show undefined attributes

affiliation	[Affiliation:1237412] University of Cambridge, Department of Biochemistry
created	[InstanceEdit:165843] de Bono, B, 2005-08-11 14:55:53
dbId	165841
displayName	Gay, NJ
firstname	Nicholas J
initial	NJ
modified	[InstanceEdit:8932050] D'Eustachio, Peter, 2016-07-20
publications	[LiteratureReference:208258] Structure and function of toll receptors and their ligands [LiteratureReference:165842] MD-2: the Toll 'gatekeeper' in endotoxin signalling [LiteratureReference:1678965] Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling [LiteratureReference:2586627] Assembly of oligomeric death domain complexes during Toll receptor signaling [LiteratureReference:208281] Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway [LiteratureReference:2559408] A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling [LiteratureReference:2428859] Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88 [LiteratureReference:208301] Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand [LiteratureReference:2206266] Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling [LiteratureReference:936981] A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins [LiteratureReference:2428864] Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly [LiteratureReference:208173] Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling [LiteratureReference:936987] An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4 [LiteratureReference:2428798] Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection [LiteratureReference:358180] Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Sp�tzle
schemaClass	Person
surname	Gay

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