The mature form of urokinase plasminogen activator receptor ...

created [InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId 162845
displayName The mature form of urokinase plasminogen activator receptor ...
literatureReference
modified [InstanceEdit:9609398] D'Eustachio, Peter, 2018-05-23
schemaClass Summation
text The mature form of urokinase plasminogen activator receptor (uPAR) is attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor (Ploug et al. 1991). As nascent uPAR polypeptide moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves the uPAR polypeptide after residue 305, releasing the carboxyterminal peptide of uPAR and replacing it with an acylated GPI moiety. In a second step, the GPI moiety is deacylated, yielding a uPAR-GPI conjugate that can be efficiently transported to the Golgi apparatus.
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