NICD translocates to the nucleus and assembles into a ternar...

created [InstanceEdit:157946] Jassal, B, 2005-01-10 12:51:46
dbId 157930
displayName NICD translocates to the nucleus and assembles into a ternar...
modified [InstanceEdit:2152408] Orlic-Milacic, M, 2012-02-27
schemaClass Summation
text NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes.
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