Reactome | Cantley, LC

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created	[InstanceEdit:139985] de Bono, B, 2004-08-12 05:56:15
dbId	140008
displayName	Cantley, LC
firstname	Lewis C
initial	LC
modified	[InstanceEdit:8952243] D'Eustachio, Peter, 2016-12-13
publications	[LiteratureReference:8855279] Phosphatidylinositol 3-kinase [LiteratureReference:1495994] AKT/PKB signaling: navigating downstream [LiteratureReference:437166] Signalling through the lipid products of phosphoinositide-3-OH kinase [LiteratureReference:914059] Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals [LiteratureReference:9029754] The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism [LiteratureReference:437159] Phosphoinositide kinases [LiteratureReference:1675796] Subcellular locations of phosphatidylinositol 4-kinase isoforms [LiteratureReference:3222275] Interferon regulatory factor-3 is an in vivo target of DNA-PK [LiteratureReference:741404] The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO [LiteratureReference:1675860] A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate [LiteratureReference:532191] Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb [LiteratureReference:1445051] Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions [LiteratureReference:2685280] Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate [LiteratureReference:199857] Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway [LiteratureReference:8933614] The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif [LiteratureReference:1250222] Ligand discrimination in signaling through an ErbB4 receptor homodimer [LiteratureReference:437174] Purification and characterization of phosphoinositide 3-kinase from rat liver [LiteratureReference:4093298] Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells [LiteratureReference:1247994] Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains [LiteratureReference:140002] Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation [LiteratureReference:5626158] TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development [LiteratureReference:5672035] Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome [LiteratureReference:1675873] Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate [LiteratureReference:380943] The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress [LiteratureReference:3508837] Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice [LiteratureReference:5657670] Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation [LiteratureReference:183083] p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase [LiteratureReference:9856996] Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors [LiteratureReference:2028648] TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins [LiteratureReference:2404155] High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability [LiteratureReference:9795419] NRF2 regulates serine biosynthesis in non-small cell lung cancer [LiteratureReference:5668890] Bidirectional transport of amino acids regulates mTOR and autophagy [LiteratureReference:879979] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate [LiteratureReference:6810384] The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor [LiteratureReference:9729344] The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro
schemaClass	Person
surname	Cantley

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