NR1D1 (REV-ERBA) binds heme and the promoter of the PGC-1alp...
| created | [InstanceEdit:1368177] May, B, 2011-06-29 |
| dbId | 1368167 |
| displayName | NR1D1 (REV-ERBA) binds heme and the promoter of the PGC-1alp... |
| literatureReference | |
| modified | [InstanceEdit:9936612] May, Bruce, 2025-01-24 |
| schemaClass | Summation |
| text | NR1D1 (REV-ERBA) binds heme and the promoter of the PGC-1alpha (PPARGC1A) gene (Wu et al. 2009). The REV-ERBA:heme complex recruits the corepressors NCoR and HDAC3 and represses transcription (Wu et al. 2009). PPARGC1A coactivates transcription by transcription factors to regulate genes such as PPARA, which is involved in mitochondrial biogenesis and energy metabolism (reviewed in .Desvergne and Wahli 1999, Sun et al. 2025). |
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