Reactome | The prolactin receptor (PRLR) peptide is a single transmembr...

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created	[InstanceEdit:1364048] Jupe, S, 2011-06-23
dbId	1364069
displayName	The prolactin receptor (PRLR) peptide is a single transmembr...
literatureReference	[LiteratureReference:1671678] Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications [LiteratureReference:1671695] Investigation of prolactin receptor activation and blockade using time-resolved fluorescence resonance energy transfer [LiteratureReference:1671707] Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2
modified	[InstanceEdit:1671654] Jupe, S, 2011-10-17
schemaClass	Summation
text	The prolactin receptor (PRLR) peptide is a single transmembrane domain protein that functions as a dimer. Recent reports suggest that like many other cytokine receptors, the prolactin receptor (PRLR) pre-assembles at the plasma membrane in the absence of ligand (Gadd & Clevenger 2006, Tallet et al. 2011), suggesting that ligand-induced activation involves conformational changes in the preformed receptor dimer (Broutin et al. 2010).

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