In neuroendocrine cells such as pancreatic alpha-, beta-, an...

created [InstanceEdit:1297414] Mahajan, SS, 2011-05-22
dbId 1297415
displayName In neuroendocrine cells such as pancreatic alpha-, beta-, an...
modified [InstanceEdit:1368972] Jassal, Bijay, 2011-07-04
schemaClass Summation
text In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.
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