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Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor... Show undefined attributes

created	[InstanceEdit:1213487] Jupe, S, 2011-02-11
dbId	1213491
displayName	Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor...
literatureReference	[LiteratureReference:451901] Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits [LiteratureReference:451906] Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta [LiteratureReference:451897] Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID [LiteratureReference:1213488] The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals [LiteratureReference:1213489] Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation [LiteratureReference:9606930] Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases
modified	[InstanceEdit:9606932] Jassal, Bijay, 2018-04-27
schemaClass	Summation
text	Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor gamma chain, Gc) associates with Tyrosine-protein kinase JAK3 (JAK3). The carboxyl-terminal region of IL2RG is important for this association (Miyazaki et al. 1994, Zhu et al. 1998, Russel et al. 2004, Chen et al.1997, Nelson et al.1994) as well as the FERM domain in JAK3 (Zhou et al. 2001).

Referrals

(summation)

[Reaction:R-HSA-451895] IL2RG binds JAK3

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