Reactome | The activation of Lyn by GHR is thought to indirectly activa...

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created	[InstanceEdit:1168454] Jupe, S, 2010-12-22
dbId	1168455
displayName	The activation of Lyn by GHR is thought to indirectly activa...
literatureReference	[LiteratureReference:1168395] An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway [LiteratureReference:1168453] Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1 [LiteratureReference:1168415] The growth hormone receptor: mechanism of activation and clinical implications
modified	[InstanceEdit:1362469] Jupe, S, 2011-06-10
schemaClass	Summation
text	The activation of Lyn by GHR is thought to indirectly activate ERK. Mutations of GHR predicted to disable a conformational change brought about by GH binding impaired ERK signaling but not JAK2/STAT5 signaling. ERK signaling was demonstrated to involve the Src family kinase Lyn (Rowlinson et al. 2008) and suggested to involve Src kinase dependent activation of Phospholipase C gamma and thereby Ras, similar to a mechanism proposed by Bivona et al. (2003). ERK activation mechanisms involving Src kinases and PLCgamma have been reported for the erythropoietin, thrombopoietin and prolactin receptors (Brooks & Waters 2010).

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