Reactome | JAKs bind to the box1 motif (residues 297-305) of the Growth...

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created	[InstanceEdit:1168344] Jupe, S, 2010-12-17
dbId	1168342
displayName	JAKs bind to the box1 motif (residues 297-305) of the Growth...
literatureReference	[LiteratureReference:982795] Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase [LiteratureReference:1168407] Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase [LiteratureReference:1168420] Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling [LiteratureReference:1169255] Janus kinase 2 enhances the stability of the mature growth hormone receptor
modified	[InstanceEdit:1362469] Jupe, S, 2011-06-10
schemaClass	Summation
text	JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).

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