Reactome | endopeptidase activity of 26S proteasome [cytosol]

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endopeptidase activity of 26S proteasome [cytosol] Show undefined attributes

activity	[GO_MolecularFunction:1793] endopeptidase activity
catalyzedEvent	[BlackBoxEvent:R-DRE-5687112] MAPK6 is degraded by the 26S proteasome - Danio rerio [BlackBoxEvent:R-DRE-450466] AUF1:mRNA complex is degraded - Danio rerio [BlackBoxEvent:R-DRE-9954728] The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide - Danio rerio [BlackBoxEvent:R-DRE-9755303] 26S proteasome degrades HIFalpha - Danio rerio [BlackBoxEvent:R-DRE-5668520] 26Sproteasome degrades K48polyUb-NIK - Danio rerio [BlackBoxEvent:R-DRE-5362448] Hh C-terminal fragments are degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-9934893] Proteolysis of K48polyUb-K,p-S-PER1,2,3 - Danio rerio [BlackBoxEvent:R-DRE-9755306] ub UBXN7 is degraded by the 26S proteasome - Danio rerio [BlackBoxEvent:R-DRE-8866553] misfolded CFTR is degraded by the 26S proteasome - Danio rerio [BlackBoxEvent:R-DRE-8932355] 26S proteasome degrades Ub-NFE2L2 - Danio rerio [BlackBoxEvent:R-DRE-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Danio rerio [BlackBoxEvent:R-DRE-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Danio rerio [BlackBoxEvent:R-DRE-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Danio rerio [BlackBoxEvent:R-DRE-5635868] ub-GLI is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-5668481] Protesomal degradation of K48polyUb-TRAF3 - Danio rerio [BlackBoxEvent:R-DRE-1236970] Proteasomal clevage of exogenous antigen (26S proteasome catalyst) - Danio rerio [BlackBoxEvent:R-DRE-353125] 26S proteosome degrades ODC holoenzyme complex - Danio rerio [Reaction:R-DRE-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Danio rerio [BlackBoxEvent:R-DRE-75825] Proteasome mediated degradation of Cyclin D1 - Danio rerio [BlackBoxEvent:R-DRE-8854071] Proteasome-mediated degradation of PolyUb-FBXL7 - Danio rerio [BlackBoxEvent:R-DRE-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Danio rerio [BlackBoxEvent:R-DRE-1168640] Ubiquitinated IkB is degraded - Danio rerio [BlackBoxEvent:R-DRE-69016] Ubiquitinated Cdc6 is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-5610754] GLI3 is partially degraded by the proteasome to yield the GLI3 repressor - Danio rerio [BlackBoxEvent:R-DRE-9766223] Proteasome-dependent degradation of ubiquitinated CDH1 - Danio rerio [BlackBoxEvent:R-DRE-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-1504193] Ubiquitinated DVL is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-4641256] Ubiquitinated AXIN is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-4608855] PRICKLE1 is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-5658430] NF1 is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-68948] Ubiquitinated Orc1 is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-DRE-1234159] Proteasome proteolyzes ub-HIF-alpha - Danio rerio [BlackBoxEvent:R-DRE-8850992] Proteasome degrades polyubiquitinated PTEN - Danio rerio [BlackBoxEvent:R-DRE-983150] Proteasomal cleavage of substrate - Danio rerio [BlackBoxEvent:R-DRE-8852354] GTSE1 facilitates proteasome-mediated degradation of TP53 - Danio rerio [BlackBoxEvent:R-DRE-264458] Proteasome mediated degradation of COP1 - Danio rerio [BlackBoxEvent:R-DRE-174105] Degradation of multiubiquitinated cell cycle proteins - Danio rerio [BlackBoxEvent:R-DRE-174202] Degradation of multiubiquitinated Securin - Danio rerio [BlackBoxEvent:R-DRE-174255] Degradation multiubiquitinated Cyclin A - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10560474
displayName	endopeptidase activity of 26S proteasome [cytosol]
physicalEntity	[Complex:R-DRE-68819] 26S proteasome [cytosol]
schemaClass	CatalystActivity

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